Tohoku J Exp Med

Peripheral blood stem cell transplantation for hepatoblastoma with microscopical residue: a therapeutic approach for incompletely resected tumor.

Year 1998
Yoshinari M. Imaizumi M. Hayashi Y. Sato A. Saito T. Suzuki H. Saisho T. Abukawa D. Ogawa E. Aikawa J. Goto K. Satoh T. Ohi R. Iinuma K.
Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan.
We report a nine-month-old boy with stage III B hepatoblastoma of caudate lobe origin. Surgical resection was attempted following six courses of chemotherapy, but viable tumor cells remained microscopically at resection margins. Subsequently, he received peripheral blood stem cell transplantation (PBSCT), whose preparative regimen being consisted of carboplatin, etoposide, tetrahydropyranyl adriamycin, and melphalan. Since then, the patient shows no relevance of local relapse or distant metastasis without any chemotherapy. PBSCT for patients with post-operative residue may improve the outcome of advanced hepatoblastoma and worth of a further clinical investigation.