Rev Esp Med Nucl

[Radiolabeling of a new agent for the study of colorectal tumors]

Year 1998
Quesada Cepero W. Pimentel Gonzalez G. Oliva Gonzalez J. Perez Tenorio G. Aguiar Cabeza E. Sanchez Monzon I. Hernandez Romero O. Rebustillo Sierra M.
Departamento de Medicina Nuclear Instituto Nacional de Oncologia y Radiobiologia Calle 29 y E. Vedado C., Habana, Cuba.
A new Monoclonal Antibody (AcMo) ior-C5, highly specific for the most part of colorectal adenocarcinomas has been developed. The AcMo was labeled with 99mTc by the Schwarz's direct method using molar ratios MAb: reductant of 1:1,000 and 1:2,000. The first molar ratio was the most adequate for the preparation of the radiopharmaceutical. A labeling yield greater than 95% was obtained. Several assays were carried out in order to evaluate the stability of the preparation, whose results reflected the presence of the stable complex 99mTc-IgG. The biodistribution patterns for both preparations were similar. The excreting organs behaved like normal. Nevertheless, a greater renal excretion was observed for the preparation of the molar ratio of 1:2.000, which could be due to the presence of low affinity sites observed in this preparation. They are vulnerable to the trans-chelation of the 99mTc toward cysteine or glutathione present in plasma and tissues.

[Hepatopulmonary syndrome and pulmonary perfusion scan]

Year 1998
Izquierdo Muro V. Gomez Duran D. Macias Fernandez E. Siurana Escuer R. Pujol del Pozo A. Martinez de Virgala Martinez C.
Servicio de Medicina Nuclear Hospital Universitario Joan XXIII de Tarragona.
We introduce you a case report of a female patient who has got a chronic liver disease and who entered our hospital with clinical suspicion of pulmonary embolism. The radionuclide lung perfusion scan using 99m Technetium-labelled with macroaggregated albumin, showed an abnormal uptake out of the lungs in liver, spleen, and kidneys. Once all possible etiologies of extrapulmonary uptake were excluded and confirming that the hepatopulmonary syndrome clinical criteria were coincident with our case, we attribute that the abnormal extrapulmonary uptake was explainable due to this syndrome. This is an hepatopulmonary syndrome case in which nuclear medicine techniques were decisive for the diagnosis in front of other diagnostic tests (radiography, echography and CT) that gave valuable but non conclusive information.