[Effects of mono- and combined peptic ulcer therapy on lipid peroxidation and antioxidant defense in ulcerous zone]
Esedov EM. Mamaev SN.
Lipid peroxidation and antioxidant activity in the margin and periulcerous zones of duodenal mucosa were investigated in 111 patients with duodenal ulcer before treatment and in periscar zone after chemotherapy allowing for Helicobacter pylori infection. In active ulcer lipid peroxidation was high while antioxidant activity was depressed. Helicobacter pylori was found able to initiate peroxidation. Pathogenetic therapy including antihelicobacter drugs inhibits activity of lipid peroxidation and promotes normalization of antioxidant activity of duodenal mucosa. This gives grounds for combined use of antisecretory and antichelicobacter medicines.
[Hepatolienal syndrome in patients with chronic lymphoid leukemia and liver cirrhosis: similarities and differences of macrophagal function]
Litvinov AV. Miliagin VA.
Macrophagal function of the liver and spleen was studied using 99mTc dynamic scintigraphy in 31 patients with chronic lymphoid leukemia (CLL) and 11 patients with hepatic cirrhosis (HC). Total accumulation of the radionuclide in the above patients took place with more active participation of the spleen and less active--of the liver. Macrophagal function of the spleen and the liver was activated in CLL patients, whereas hepatic cirrhosis was accompanied by enhanced splenic function and diminished capacity of the liver for phagocytosis. Mechanisms of such phenomena are discussed.
[Antigliadin antibodies in the absence of celiac disease]
Kamaeva OI. Reznikov IuP. Pimenova NS. Dobritsyna LV.
Antigliadin antibodies (AGA) mark celiac disease, but AGA are also encountered in IgA-nephritis, psoriasis, sickle-cell anemia, hepatic disorders, juvenile rheumatoid arthritis, autoimmune thyroidism and in persons who occupationally contact great amounts of wheat. AGA IgA and/or IgG were registered in 19 of 60 subjects (51 adults and 9 children) with various immunomediated diseases without symptoms of celiac disease: in 4 cases of chronic active hepatitis, in 2 of 4 cases of chronic persistent hepatitis, in 4 of 16 cases of rheumatoid arthritis, in 3 of 19 cases of IgA-deficiency, in 1 of 8 cases of SLE, in 2 cases of postvaccine reaction, in all the single cases of juvenile rheumatoid arthritis, focal scleroderma, macroglobulinemia. IgA only occurred in in 6 patients, IgG- in 6 patients, both IgA and IgG in 7 patients. The most pronounced positive reaction to AGA was recorded in 8-year-old girl with juvenile rheumatoid arthritis. The emergence of AGA in immunomediated diseases may be attributed to the response to food protein in pathological conditions and is often unrelated closely with celiac disease.
[Melatonin production in patients with duodenal ulcer at different stages of disease]
Komarov FI. Rapoport SI. Malinovskaia NK. Voznesenskaia LA. Sharov AA. Vetterberg L.
Melatonin secretion was measured in patients with duodenal ulcer in exacerbation and remission. Melatonin production was found abnormal both in duodenal ulcer remission and exacerbation. It is suggested that melatonin may participate in pathogenesis of duodenal ulcer.
[Factors underlying gastroduodenal pathology in children]
Kil'diiarova RR. Kolesnikova MB.
Correlation analysis conducted in 106 children with chronic gastroduodenitis enabled us to distinguish leading factors in the onset of this disease, to estimate the strength of connection between clinicoanamnestic and laboratory-instrumental methods of investigation. A strong correlation was found in children with gastroduodenitis between changes of sialo-containing compounds, secretory IgA in the saliva and inflammation severity.