Hepatitis C virus and renal transplantation.
Morales JM. Campistol JM. Andres A. Rodicio JL.
Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
During the past 12 months additional evidence has emerged from several studies, indicating that hepatitis C virus infection is the most important liver disease after renal transplantation. A new, severe and rare entity called fibrosing cholestatic hepatitis can lead to early liver failure, although the most important complications appeared in the long-run. Encouraging results with ribavirin have been described. Although glomerular lesions and more severe infections can appear in hepatitis C virus patients, graft and patient survival rates in most series are similar to those in hepatitis-C-negative patients. Survival is also better among hepatitis-C-positive patients after renal transplantation than in hepatitis-C-positive patients on dialysis on the waiting list for transplantation. Finally, the use of kidneys from hepatitis-C-positive donors is suggested for transplant into hepatitis C RNA positive patients matching the hepatitis C genotype.