AJNR Am J Neuroradiol

Acquired hepatocerebral degeneration: MR and pathologic findings.

Year 1998
Lee J. Lacomis D. Comu S. Jacobsohn J. Kanal E.
Department of Radiology, University of Pittsburgh School of Medicine, PA 15213, USA.
Acquired (non-Wilsonian) hepatocerebral degeneration (AHD) is a rare irreversible neurologic syndrome that occurs in patients with chronic liver disease associated with multiple metabolic insults. The pathophysiology and the locations of the cerebral injuries are incompletely understood. We describe a patient with fatal hepatic cirrhosis and AHD in whom MR images showed abnormalities in the brachium pontis bilaterally. Neuropathologic evaluation disclosed multiple regions of subcortical spongiform white matter changes.

Isolated cortical venous thrombosis and ulcerative colitis.

Year 1998
Derdeyn CP. Powers WJ.
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.
Aseptic cortical venous thrombosis is rare without concomitant dural sinus thrombosis. Ulcerative colitis is associated with both dural sinus thrombosis and isolated cortical venous thrombosis. We describe a 26-year-old woman with ulcerative colitis who had a spontaneous cerebral hemorrhage. An overlying thrombosed cortical vein was identified on spin-echo MR images and confirmed with angiography. Signal characteristics of thrombosed cortical veins are similar to those described in dural sinus thrombosis.