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Adv Enzymol Relat Areas Mol Biol

gamma-Glutamyl transpeptidase: catalytic mechanism and gene expression.

Year 1998
Taniguchi N. Ikeda Y.
Department of Biochemistry, Osaka University Medical School, Japan.
The gamma-glutamyl transpeptidases are key enzymes in the so-called gamma-glutamyl cycle involving glutathione synthesis, the recovery of its constituents, and in the transport of amino acids. This membrane-bound ectoenzyme thus serves to regulate glutathione synthesis. This chapter deals with the active site chemistry of gamma-glutamyl transpeptidase, including the role of side-chain groups on the light subunit as well as several serine residues in the catalytic process. Also considered are genomic studies indicating (a) the presence of a single gene in mouse and rat; (b) the occurrence of multiple genes in humans; (c) the involvement of multiple promoters for gene expression; and (d) how these multiple promoters may play a role in the tissue-specific expression of gamma-glutamyl transpeptidases.

Источник: https://gastroportal.ru/science-articles-of-world-periodical-eng/adv-enzymol-relat-areas-mol-biol.html
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