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Shimada H. Nakajima K. Ochiai T. Koide Y. Okazumi SI. Matsubara H. Takeda A. Miyazawa Y. Arima M. Isono K.
Department of Surgery, School of Medicine, Chiba University, Chuou-ku, Chiba 260-8670, Japan.
The significance of serum p53-Abs in patients with esophageal squamous cell carcinoma was determined. Examination of clinicopathological features and assessment of tumor marker sensitivities of carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC-Ag) and CYFRA21-1 were performed. Thirty-three (58%) of 57 patients were positive for serum p53-Abs, however, no relation with cancer progression existed. Fourteen of the 33 sero-positive patients revealed normal levels of all tumor markers tested. Thus, serum p53-Abs appears to be a useful marker for the detection of esophageal squamous cell carcinoma.