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Kikuyama S. Kubota T. Shimizu K. Miyakita M.
Department of Surgery, Saiseikai Central Hospital, Minato-ku, Tokyo 108-0073, Japan.
One hundred and thirty surgical specimens of gastric adenocarcinoma were obtained from patients who had undergone radical gastrectomy. The samples were formalin-fixed, paraffin-embedded and used for immunostaining of Ki-67 antigen. Mean Ki-67 index was 41.8% (SD 15. 7%, range 8.2-84.2%). Differentiated carcinomas had a higher Ki-67 index than undifferentiated tumors, although other clinicopathological variables, including lymph node metastasis and depth of invasion showed no correlation with Ki-67 index. In the undifferentiated tumors, Ki-67 index correlated with lymph node involvement. A high Ki-67 index ( 55%) was found to be an independent indicator of poor prognosis in patients with undifferentiated tumors.